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Published on April 09, 2015

Sirolimus (Rapamycin)

Tube Type = Lavendar Top

Tube Type

Test ID   LAB875
EPIC ORDER
   SIROLIMUS, LEVEL
CPT Code(s)   80195
Group/Individual Test   Individual
Laboratory   Special Chemistry Laboratory
Tube Station   30
Specimen Routine: 3 mL blood/lavender EDTA tube; See Comments
Micro: 500 µL blood/lavender EDTA microtainer 
Stability Room Temperature: 14 days
2-8°C: 14 days
Frozen: NOT ACCEPTABLE
Off Site Collections: Ambient/Room Temp. is acceptable. Samples may be refrigerated (2 - 8°C). Do NOT freeze. Ship ambient or with refrigerated cold pack(s) only. Do NOT use dry ice. Do NOT use frozen cold packs.
Availability Routine: Daily
  STAT: N/A
Turnaround Time  

Samples for sirolimus testing must be in the Core Laboratory by 12 pm (noon) for same day testing.

Results available by ~5pm.
Reference Range Therapeutic: 3.0 - 20.0 ng/mL(Trough, steady state)
Critical Value Range

Greater than 20 ng/mL

The above ranges are published as rough guidelines only. Concentrations targeted depend upon the drug regimen used, the type of transplant, time post-transplantation, and other clinical factors such as renal function, rejection status, etc.
Comments
  • Sirolimus should be collected as a trough sample immediately before the next scheduled dose.
  • Methodology:  Liquid Chromatography Tandem Mass Spectrometry
  • Multiple test requests with the same sample type will require additional volumes for testing
  • Pediatric microtainer devices available from Phlebotomy Services

Reviewed by J.Carr on November 19, 2025

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514