Published on April 09, 2015

Sirolimus (Rapamycin)

Tube Type

Test ID   LAB875
CPT Code(s)   80195
Group/Individual Test   Individual
Laboratory   Perfomed by: Special Chemistry Laboratory
Tube Station   30
Specimen Routine: 5 mL blood, lavender top blood collection tube; see  comments
  Micro: 500 ul blood/ lavender top microcollection device
Room Temperature: 14 days
Off Site Collections:
Ambient/Room Temp. is acceptable. Samples may be refrigerated (2 - 8°C). Do NOT freeze. Ship ambient or with refrigerated cold pack(s) only. Do NOT use dry ice. Do NOT use frozen cold packs.
Ambient: 14 Days
Refrigerated: 14 Days
Frozen - Not Acceptable
Availability Routine: Daily; Not available STAT
Turnaround Time  

Samples for sirolimus testing must be in the Core Laboratory by 12 pm (noon) for same day testing.

Results available by ~5pm.

Reference Range Therapeutic: 3.0 - 20.0 ng/mL(Trough, steady state)
Critical Value Range

Greater than 20 ng/mL

The above ranges are published as rough guidelines only. Concentrations targeted depend upon the drug regimen used, the type of transplant, time post-transplantation, and other clinical factors such as renal function, rejection status, etc.


Methodology:Liquid Chromatography Tandem Mass Spectrometry

-Sirolimus should be collected as a trough sample immediately before the next scheduled dose.
-Multiple test requests with same sample type will require additional volumes for testing.
-Pediatric microcollection devices available from Phlebotomy Services

Reviewed by Christopher Parker on November 01, 2021

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514