Lyme Disease Serology

Tube Type

Test ID   LAB5354
EPIC Order
CPT Code(s)   86618
Group/Individual Test   Individual
Laboratory   Clinical Immunology
Tube Station   30
Specimen Routine: 2 mL blood/Serum Separator Tube/Gold Top
Availability Routine: Monday - Friday
Turnaround Time   1 - 3 Days
Reference Range Normal: Negative:  See Important Comments.

All lyme disease serology samples are tested using a qualitative, chemiluminescence immunoassay for the detection of IgG and IgM antibodies to the VlsE protein of Borrelia burgdorferi in human serum samples.  The test is intended as an aid in the diagnosis of Lyme disease.  Results are reported as negative or See Western Blot.  A negative result indicates the absence of detectable Borrelia burgdorferi antibodies. A negative result does not exclude the possibility of Borrelia burgdorferi infection. If early Lyme disease is suspected, a second sample should be collected and tested two to four weeks later.  A positive result indicates the presence of detectable Borrelia burgdorferi antibodies. Current testing guidelines  (MMWR. August 11, 1995 / 44(31);590-591) recommend that all positive results be supplemented by further testing in a standardized Western blot assay. Positive and equivocal samples are reflexed to a sendout Western blot assay via the Referral Testing Laboratory.  See also:

Reviewed by jcarr on November 30, 2021

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514