Histoplasma/Blastomyces Antigen, Urine

Component of Histoplasma/Blastomyces Ab/Ag order set

Container Type

Test ID LAB400
EPIC ORDER
 HISTO/BLASTO ANTIGEN URINE
CPT Code(s) 87449
Group/Individual Test Group
Laboratory Core Referral Testing
Tube Station 30
Specimen Routine: 10 mL urine in random container; See comments
Micro: 2.5 uL
Availability Routine: Reference Laboratory - Mayo Clinic Laboratories (MiraVista Laboratories when reflexed)
Turnaround Time 5-10 days
Reference Range Normal: See separate report
Comment
  • Histoplasma capsulatum and Blastomyces spp. antigens are both detected, but not differentiated, by this test.
  • Histoplasma/Blastomyces Urine Antigen is the preferred initial non-invasive testing for blastomycosis per CDC and Mycosis Study Group guidelines.
  • Serial antigen levels can be monitored for treatment response after initiation of anti-fungal therapy.
  • Histoplasma/Blastomyces Urine Antigen should be ordered in combination with Histoplasma Antibody per CDC and Mycoses Study Group recommendations for non-invasive testing of Histoplasmosis. 

Reviewed by J. Carr on November 12, 2025

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514