EBV Serologies (Epstein-Barr Virus Antibodies)
Tube Type
Includes: Viral Capsid Antigen (VCA), Capsid IgG, Capsid IgM,
and Epstein Barr Virus Nuclear Antigen (EBNA)
| Test ID |
|
LAB863 |
EPIC Order
|
|
Epstein-Barr Virus (EBV) Antibody Panel |
| CPT Code(s) |
|
86664, 86665 x2 |
| Group/Individual Test |
|
Group |
| Laboratory |
|
Immunology |
| Tube Station |
|
30 |
| Specimen |
Routine: |
4 mL blood/Gold SST tube |
| Availability |
Routine: |
Monday-Friday |
| |
STAT: |
N/A |
| Turnaround Time |
|
3-5 days |
| Reference Range |
Normal: |
See comments |
|
|
|
|
|
|
| Comments |
|
- Specimens submitted for EBV specific serologic testing are assayed for Viral Capsid Antigen (VCA) IgG, VCA IgM and Epstein Barr Virus Nuclear Antigen (EBNA) IgG using a qualitative, chemiluminescent immunoassay for the determination of: IgG and IgM antibodies to VCA; IgG antibodies to EBNA in human serum. VCA IgM antibodies usually disappear in 2-3 months after infection while IgG antibodies persist indefinitely. IgG antibodies to Epstein-Barr Nuclear Antigen (EBNA) appears several weeks or months after on-set of disease and persist for years or even life. (For a review see PMID: 24175209)
|
Anti-EBV antibodies
|
Interpretation
|
|
VCA IgM
|
VCA IgG
|
EBNA-1 IgG
|
|
|
Negative
|
Negative
|
Negative
|
No immunity
|
|
Positive
|
Negative
|
Negative
|
Acute infection or non-specificity
|
|
Positive
|
Positive
|
Negative
|
Acute infection
|
|
Negative
|
Positive
|
Positive
|
Past infection
|
|
Negative
|
Positive
|
Negative
|
Acute or past infection
|
|
Positive
|
Positive
|
Positive
|
Late primary infection or reactivation
|
|
Negative
|
Negative
|
Positive
|
Past infection or non-specificity
|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/
|
