Oligoclonal Banding Evaluation


Tube Type

CSF Protein Electrophoresis with Ratio

Serum Albumin, Serum IgG, CSF Albumin, CSF IgG, CSF IgG Index, CSF IgG/Albumin Ratio, Interpretation.

Test ID LAB740
CPT Code(s) 84166 x2
Group/Individual Test Group
Laboratory Performed by Core & Special Chemistry Laboratories
Tube Station 30
Specimen Routine: 2 ml CSF, tube 2; plus 2 mL blood/serum separator tube/gold top; see Comments
Micro: 2 ml CSF, tube 2; plus 1.5 mL blood/serum separator tube/gold top;see Comments
Stability: Refrigerated (2-8° C):
Frozen:  1 month
Frozen: 1 month
Availability Routine: Specimens are tested within 7 days of receipt.
Turnaround Time 7 Days
Reference Range Normal: Interpretation is provided on patient report; call (984)974-2361 with questions.

Reference Ranges:

CSF IgG 0.5-7.0 mg/dL
CSF Albumin 5.0-35.7 mg/dL
CSF IgG Index 0.3-0.8
CSF Oligoclonal Bands Negative: No bands unique to CSF observed
Albumin, serum 3.5-5.0 g/dL
IgG, serum Birth 600-1635 mg/dL
1-3 mos 310-860 mg/dL
3-12 mos 310-950 mg/dL
12-24 mos 400-1040 mg/dL
2-6 years 425-1300 mg/dL
6-10 years 490-1400 mg/dL
10 years-adult 600-1700 mg/dL

Ratio Interpretation: Normal-The CSF Albumin/Serum Albumin Ratio indicates normal permeability of the blood brain barrier and the IgG index does not suggest increased intrathecal IgG synthesis.

Centrifuge, separate, and refrigerate serum sample within 4 hours of collection.
This test is used to identify oligoclonal bands in the CSF of patients with neurological symptoms (such as multiple sclerosis).
A paired serum sample is required. Both samples should be collected at the same time; samples collected >24 hrs apart may be rejected. Transport samples to laboratory together.

Not to be used to detect CSF leakage (Beta-2 Transferrin, Fluid).

Method Isoelectric Focusing

Reviewed by Christopher Parker on November 01, 2021

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514