Oligoclonal Banding Evaluation
(both)
Tube Type
CSF Protein Electrophoresis with Ratio
Includes:
Serum Albumin, Serum IgG, CSF Albumin, CSF IgG, CSF IgG Index, CSF IgG/Albumin Ratio, Interpretation.
| Test ID |
LABO596461 |
| EPIC ORDER |
OLIGOCLONAL BANDING |
| CPT Code(s) |
83916 x2 OLIGOCLONAL BANDING
82040, 82784 SERUM IgG & ALBUMIN FOR OLIGOCLONAL BANDING
82784 IgG, CSF
82042 ALBUMIN, CSF
|
| Group/Individual Test |
Group |
| Laboratory |
Core & Special Chemistry Laboratories |
| Tube Station |
30 |
| Specimen |
Routine: |
2 ml CSF, tube 2; plus 2 mL blood/Gold SST tube; See Comments |
| Micro: |
2 ml CSF, tube 2; plus 1.5 mL blood/Gold SST microtainer |
| Stability: |
Refrigerated (2-8° C): |
7 days |
| Frozen: |
1 month |
| Availability |
Routine: |
Specimens are tested within 7 days of receipt. |
| Turnaround Time |
7 Days |
| Reference Range |
Normal: |
| CSF IgG |
|
≤7.0 mg/dL |
| CSF Albumin |
|
7.1-35.7 mg/dL |
| CSF IgG Index |
|
0.3-0.8 |
| CSF Oligoclonal Bands |
Negative: |
No bands unique to CSF observed |
| Albumin, serum |
|
3.4-5.0 g/dL |
|
|
|
|
Age |
IgG, mg/dL |
| IgG, serum |
0-<1 year* |
136-890 mg/dL |
|
1-<4 years* |
443-1243 mg/dL |
|
4-<10 years* |
566-1359 mg/dL |
|
10-<19 years* |
684-1581 mg/dL |
|
19 yrs + |
650-1600 mg/dL |
* Pediatric reference ranges from Caliper study (Advia) https://pubmed.ncbi.nlm.nih.gov/30550936/ (1-4 yr range adjusted).
Ratio Interpretation: Normal-The CSF Albumin/Serum Albumin Ratio indicates normal permeability of the blood brain barrier and the IgG index does not suggest increased intrathecal IgG synthesis.
Interpretation is provided on patient report; call (984)974-2361 with questions
|
| Comments |
- Centrifuge, separate, and refrigerate serum sample within 4 hours of collection.
- A paired serum sample is required. Both samples should be collected at the same time; samples collected >24 hrs apart may be rejected. Transport samples to the laboratory together.
- Methodology: Isoelectric Focusing
This test is used to identify oligoclonal bands in the CSF of patients with neurological symptoms (such as multiple sclerosis).
- Not to be used to detect CSF leakage (Beta-2 Transferrin, Fluid).
|
