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Cryptococcal Ag, Blood

Tube Type

Test ID   LAB779
EPIC Order
CPT Code(s)   86403, (86406 if positive)
Group/Individual Test   Individual
Laboratory   Clinical Immunology (Day Shift, M-F)
Clinical Microbiology (Weekends, Evenings, Nights)
Tube Station   30 (Routine)
82 (STAT)
Specimen Routine: 2 ml blood/Serum Separator Tube/Gold Top
Availability Routine: Monday-Friday
  STAT: YES (24 Hours/7 Days/Week)
Turnaround Time   2 hours (STAT); 1-3 days(Routine) For STAT requests, please call 984-974-1815 (Dayshift Mon-Sat), 984-974-1805 (after hours)
Reference Range Normal: Negative
Comments The Immy CrAg Lateral Flow Assay is a dipstick sandwich immunochromatographic test system for the qualitative or semi-quantitative detection of the capsular polysaccharide antigens of Cryptococcus species complex in serum and cerebral spinal fluid (CSF).  The lateral flow device is placed into a tube containing sample and diluent.  Specimen wicking is used to capture gold-conjugated, anti-CrAg monoclonal antibodies and gold-conjugated control antibodies deposited on the test membrane.  If CrAg is present in the specimen, then it binds to the gold-conjugated, anti-CrAg antibodies.  The gold-labeled antibody-antigen complex forms a sandwich at the test line causing a visible line to form.  Results are reported as negative or positive.  Positive results are accompanied by the endpoint titer determined by serial dilution of the specimen.

Reviewed by jcayless on December 02, 2019

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514