Cryptococcal Ag, Blood

Tube Type

Test ID		LAB779
EPIC Order		CRYPTOCOCCAL ANTIGEN, SERUM
CPT Code(s)		86403, (86406 if positive)
Group/Individual Test		Individual
Laboratory		Clinical Immunology (Days, Evenings, Weekends) Clinical Microbiology (Only Nights)
Tube Station	Routine:	30
Tube Station	STAT:	82 For STAT requests see Availability
Specimen		2 ml blood/gold SST tube
Availability	Routine:	Monday-Friday
	STAT:	For STAT requests, please call: Monday-Saturday, 8am - 4pm: 984-974-1815 After Hours: 984-974-1805
Turnaround Time		2 hours (STAT); 1-3 days (Routine)
Reference Range	Normal:	Negative
Comments		The Immy CrAg Lateral Flow Assay is a dipstick sandwich immunochromatographic test system for the qualitative or semi-quantitative detection of the capsular polysaccharide antigens of Cryptococcus species complex in serum and cerebral spinal fluid (CSF). The lateral flow device is placed into a tube containing sample and diluent. Specimen wicking is used to capture gold-conjugated, anti-CrAg monoclonal antibodies and gold-conjugated control antibodies deposited on the test membrane. If CrAg is present in the specimen, then it binds to the gold-conjugated, anti-CrAg antibodies. The gold-labeled antibody-antigen complex forms a sandwich at the test line causing a visible line to form. Results are reported as negative or positive. Positive results are accompanied by the endpoint titer determined by serial dilution of the specimen.

Reviewed by J. Carr on December 08, 2025

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514