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  • Chlamydia trachomatis and Neisseria gonorrhoeae NAA (Nucleic Acid Amplification and Detection)

Chlamydia trachomatis and Neisseria gonorrhoeae NAA (Nucleic Acid Amplification and Detection)

Specimen Type

Test ID LAB5814
EPIC Order
CHLAMYDIA/GONORRHOEAE NAA
CPT Code(s) 87491, 87591
Group/Individual Test Group
Laboratory Molecular Microbiology
Tube Station 82
Specimen Routine:
Urine(First stream) (2-30mL)
Endocervical swab
Urethral swab (Males only)
Vaginal swab
Rectal swab
Throat swab
Ocular swab

See Comments for additional specimen information
Availability Routine: Monday through Friday
Turnaround Time 3 days
Comments

Assay performed using the FDA-approved Gen-Probe Panther Aptima Combo2 test.

1. First stream urine samples are stable at room temperature for up to 24 hours, including transportation time. Urine specimens must be first-stream, with no urination within the last hour. Patient collection volumes for urine must be no less than 2mL, and no more than 30mL AT COLLECTION. Higher collection volumes of urine will result in decreased sensitivity, and will not be accepted. Specimens must not be poured-off to obtain a 30mL volume. Clean catch and catheterized urines are not acceptable.

A negative urine result for a female patient who is clinically suspected of having a gonococcal infection does not rule-out the presence of Neisseria gonorrhoeae in the urogenital tract. Further, a negative urine result for N. gonorrhoeae from a female has a lower negative predictive value than does an endocervical swab result. Testing of endocervical or vaginal specimens is recommended for female patients who are clinically suspected of having a gonococcal infection.

2. Swabs should be held and transported at room temperature. Refer to swab specimen collection guides for correct collection and transport. Use ONLY the Gen-Probe APTIMA collection kit for swab samples. ONLY THE BLUE swab is to be submitted to the laboratory – specimens submitted on the WHITE swab, or containing both WHITE and BLUE swabs will be rejected. NOTE: The Gen-Probe swabs are NOT acceptable for culture of any type.

Vaginal swabs should not replace cervical exams and endocervical swab specimens.

3. Test of Cure C. trachomatis NAAT testing can be ordered using the combination test as indicated above, but write in the comment line “CHLAMYDIA TOC ONLY”. In general, practitioners should consider testing for BOTH chlamydia and gonorrhea with each specimen as the risk factors, signs and symptoms are not distinguishable. Note that test of cure for chlamydia is only recommended by the CDC for pregnant women. Testing should be performed 3 weeks after the completion of therapy, or the results may be falsely positive.
4.   If you suspect therapeutic failure for gonorrhea, please contact the Microbiology Lab at 984-974-1830 to arrange antimicrobial susceptibility testing to be performed by the CDC.


Test sensitivity and specificity data are available here.

Reviewed by Christopher Parker on February 28, 2018

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514

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