Published on March 17, 2021

Dysautonomia, Autoimmune/Paraneoplastic Eval, Serum

Includes:  AChR Ganglioninc Neuronal AB S, Anti-Neuronal Nuclear Ab Type 1, CASPR2-IgG CBA S, CRMP-5-IgG S, DPPX Ab IFA S, LGI1-IgG CBA S, Purkinje Cell Cytoplasmic Ab Type 2.

Reflexed Tests:  AMPA-R Ab CBA S, AMPA-R IF Titer Assay S, Amphiphysin Ab S, Amphiphysin Immunoblot S, ANNA-1 Immunoblot S, ANNA-2 Immunoblot S, CRMP-5-IgG Western Blot S, DPPX Ab CBA S, DPPX AB IFA Titer S, GABA-B-R Ab CBA S, GABA-B-R Ab IF Titer Assay S, NMDA-R Ab CBA S, NMDA-R Ab IF Titer Assay S, PCA-1 Immunoblot S, PCA-Tr Immunoblot S, Purkinje Cell Cytoplasmic Ab Type 1, Purkinje Cell Cytoplasmic Ab Type Tr

Tube Type

Test ID   LAB11401
  Dysautonomia, Autoimmune/Paraneoplastic Eval, Serum
CPT Code(s)   83519, 86255x6 (83519, 84182x6, 86255x7, 86256x4, if appropriate)
Group/Individual Test   Group
Laboratory   Core Referral Testing
Tube Station   30
Specimen Routine: 10 mL blood/red top/SST is acceptable; see comments 
  Micro: 7.5 mL blood
Availability Routine: Reference Laboratory - Mayo  Clinic Laboratories
Turnaround Time   12-14 days
Reference Range Normal: See separate report

1. For optimal antibody detection, specimen collection is recommended before initiation of immunosuppressant medication or intravenous immunoglobulin treatment. 

2. This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate is the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received int he laboratory will be held 1 week and assayed if sufficiently decayed, or canceled or radioactivity remains. 

3. Patient should have no general anestetic or muscle-relaxant medications in the previous 24 hours. 

Reviewed by jcayless on May 10, 2022

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514