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  • AMA: Mitochondrial Ab

AMA: Mitochondrial Ab

Tube Type
Test ID   LAB513
EPIC Order
  ANTIMITOCHONDRIAL ANTIBODY
CPT Code(s)   83516
Group/Individual Test   Individual
Laboratory   Clinical Immunology
Tube Station   30
Specimen Routine: 4 mL blood/serum separator tube/gold top
  Micro: 3 microtainers/1.2 mL blood
Availability Routine: Once a week
Turnaround Time    7 days
     

Internal Reference Testing Specimen Handling Instructions:

Centrifuge, aliquot, freeze


Reference Ranges
  See Below
Comments

Testing for anti-mitochondrial antibody (AMA) is performed by ELISA using affinity purified recombinant MIT3 antigen.  The MIT3 antigen contains immuno-dominant portions of the pyruvate dehydrogenase complex (PDC-E2), the branched-chain 2-oxo-acid dehydrogenase complex (BCOADC-E2), and the 2-oxo glutarate dehydrogenase complex (OGDC-E2).  The ELISA assay used is a qualitative test that generates results in arbitrary units.  The results of the AMA test will be reported as "Negative", "Equivocal" or "Positive" based on the following:

Negative </=20.0 units
Equivocal 20.1-24.9 units
Positive >/=25.0 units
A negative result indicates no antibody or antibody levels below the detection
limit of the assay.  Equivocal results should prompt the collection and retesting of a new sample at a later time.  A positive result indicates the presence of antibody to the MIT3 antigen.  The level of antibody cannot be correlated to an endpoint titer as this is a qualitative test.  AMAs are detected in up to 95% of patients with Primary Biliary Cirrhosis.

Reviewed by gloria_crawford on October 24, 2017

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514

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