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5-Methyltetrahydrolfolate, CSF

Tube Type = Gold Top

Tube Type

Test ID LAB6012
EPIC ORDER CSF 5-METHYLTETRAHYDROFOLATE
CPT Code(s) 82542
Group/Individual Test Group
Laboratory Core Referral Testing
Tube Station N/A
Specimen Routine: 0.5-1.0 mL CSF on dry ice, See Comment
Availability Routine: Reference Laboratory - LabCorp MNG Laboratories
STAT: N/A
Turnaround Time 2-3 weeks
Reference Range Normal: See separate report 
Comments
  • Collection kit is kept in the McLendon Lab Core Lab Processing Refrigerator. Call Referral Testing with questions about collection 984-974-1414.
  • Preferred collection: Use special kit provided by reference lab which contains 5 numbered vials. Vials should be collected in order (1-5) and be the first thing collected and placed on dry ice at the bedside. If dry ice isn’t available, place samples on wet ice and deliver to Referral Testing as soon as possible.  
    • Vial number 1 is used for Neurotransmitter Metabolites and must have first drops from lumbar puncture collected up to the line on the tube. Do not collect CSF above the line.
    • Vial number 3 contains a preservative that is required for Tetrahydrobiopterin/Neoptin.
    • Vials 2, 4, 5 will be used for other testing requested at LabCorp MNG Laboratories.
  • Alternate collection: Collect CSF in small plain collection tubes and number the tubes in order of collection. Tube number 1 must have exactly 0.5mL of CSF. Tetrahydrobiopterin/Neoptin will not be available if not collected in the reference lab supplied kit.

Note: If sample is bloody, do not place samples on dry ice. Deliver them immediately to Referral Testing to be spun prior to freezing. 

Reviewed by J. Carr on December 12, 2025

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514