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  • Tacrolimus; Trough

Tacrolimus; Trough

Tube Type

Test ID LAB5367
EPIC ORDER
  TACROLIMUS LEVEL , TROUGH
CPT Code(s)   80197
Group/Individual Test   Individual
Laboratory   Core- performed by: Special Chemistry Lab
Tube Station   30
Specimen Routine: 5 mL blood/lavender top tube (EDTA); see Comments
  Micro: 500 µL blood/lavender top microtainer
Stability

Room Temperature: 14 days

Off Site Collections:
Ambient/Room Temp. is acceptable. Samples may be refrigerated (2 - 8°C). Do NOT freeze. Ship ambient or with refrigerated cold pack(s) only. Do NOT use dry ice. Do NOT use frozen cold packs.
Ambient: 14 Days
Refrigerated: 14 Days
Frozen - Not Acceptable
Availability Routine: Daily; Not available STAT; see Comments
Turnaround Time   Samples for tacrolimus testing must be in the Core Laboratory by 12pm(noon) for same day testing. Samples received after noon will be run the following day.
Results are available by 4pm.
Reference Range   5-15 ng/mL (trough, steady state).
Tacrolimus reference ranges vary with protocol, organ type, time since transplant, and patient status. Contact laboratory, pharmacy, or transplant co-ordinator for more information.
Internal Reference Testing Specimen Handling Instructions: Whole blood, Refrigerate
Critical  Value Range

Greater than 20 ng/mL

The above ranges are published as rough guidelines only. Concentrations targeted depend upon the drug regimen used, the type of transplant, time post-transplantation, and other clinical factors such as renal function, rejection status, etc.

Comments
Methodology: Liquid Chromatography Tandem Mass Spectrometry

Trough samples are used for routine monitoring, and should be collected immediately before the next dose.

-Samples must be received in the Core Laboratory by 12:00 PM for same day testing.
-Samples received in lab after 12:00 pm will be run next day.
-Multiple test requests with same sample type will require additional volumes for testing.
-Pediatric microtainers (“bullets”) available from Phlebotomy Services

Reviewed by gloria_crawford on January 31, 2017

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514

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