Alert
In This Section

Available Tests

  • EBV Serologies (Epstein-Barr Virus Antibodies)

EBV Serologies (Epstein-Barr Virus Antibodies)

Tube Type

Includes: Viral Capsid Antigen(VCA),Capsid IgG, Capsid IgM,
and Epstein Barr Virus Nuclear Antigen(EBNA)

Test ID   LAB863
EPIC Order
  Epstein-Barr Virus (EBV) Antibody Panel
CPT Code(s)   86664, 86665 x2
Group/Individual Test   Group
Laboratory   Immunology
Tube Station   30
Specimen Routine: 4 mL blood/Serum Separator Tube/Gold Top
  micro: 3 microtainers/1.5 mL blood
Availability Routine: Monday-Friday 
  STAT: N/A
     
Turnaround Time   1-4 days
Reference Range Normal: See comments.

Internal Reference Testing Specimen Handling Instructions:

Centrifuge, Refrigerate
Comments  

Specimens submitted for EBV specific serologic testing are assayed for Viral Capsid Antigen (VCA) IgG, VCA IgM and Epstein Barr Virus Nuclear Antigen (EBNA) IgG  using a qualitative, chemiluminescent immunoassay for the determination of: IgG and IgM antibodies to VCA; IgG antibodies to EBNA in human serum.  VCA IgM antibodies usually disappear in 2-3 months after infection while IgG antibodies persist indefinitely.  IgG antibodies to Epstein-Barr Nuclear Antigen (EBNA) appears several weeks or months after on-set of disease and persist for years or even life. (For a review see PMID: 24175209)

Anti-EBV antibodies

Interpretation

VCA IgM

VCA IgG

EBNA-1 IgG

 

Negative

Negative

Negative

No immunity

Positive

Negative

Negative

Acute infection or non-specificity

Positive

Positive

Negative

Acute infection

Negative

Positive

Positive

Past infection

Negative

Positive

Negative

Acute or past infection

Positive

Positive

Positive

Late primary infection or reactivation

Negative

Negative

Positive

Past infection or non-specificity

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782265/

 

Reviewed by gloria_crawford on June 21, 2016

Note: Reference ranges provided on this web site are for guidance only, and may not reflect the most recent changes. Refer to laboratory reports for current reference data.

UNC Hospitals
McLendon Clinical Laboratories
101 Manning Drive
Chapel Hill, NC 27514

Top